Spaet T H, Tiell M L, Cintron J, Won J
Thromb Res. 1982 Jul 15;27(2):205-10. doi: 10.1016/0049-3848(82)90200-6.
The hypothesis was tested, in rats and rabbits, that selective medial injury may lead to arterial intimal hyperplasia. Lesions were produced by passage of a micro-suture through the arterial wall without penetration to the lumen, or controls in which the suture did penetrate. Vessels were examined histologically at intervals up to 2 weeks after suturing. Only vessels with penetrating sutures developed intimal hyperplasia, suggesting that medial injury alone is insufficient for the production of arteriosclerosis.
在大鼠和兔子身上对选择性内侧损伤可能导致动脉内膜增生这一假说进行了验证。通过将微缝线穿过动脉壁但不穿透管腔来制造损伤，或者制造缝线确实穿透的对照情况。在缝合后长达2周的时间间隔内对血管进行组织学检查。只有缝线穿透的血管出现了内膜增生，这表明单纯的内侧损伤不足以引发动脉硬化。
