Prescott M F, McBride C K, Court M
Research Department, CIBA-GEIGY Corporation, Summit, New Jersey.
Am J Pathol. 1989 Nov;135(5):835-46.
A model was developed to study the role of leukocytes in the development of vascular lesions. Implantation of an endotoxin-soaked cotton thread in the adventitia on the ventral side of the rat femoral artery resulted in leukocyte migration into the vessel wall exclusively in the ventral half of the vessel. Leukocyte migration occurred from both the luminal and adventitial side and consisted of neutrophils and mononuclear cells. Smooth muscle cell rich intimal lesions localized to the ventral half of the vessel were first observed 1 week after implantation. Lesions remained localized to the ventral half of the vessel wall through the 6th week. When leukocyte migration into the vessel wall was inhibited by treatment with dexamethasone, lesion development did not occur. These results suggest that leukocytes can stimulate smooth muscle cell migration into the intima and result in intimal lesion formation.
建立了一个模型来研究白细胞在血管病变发展中的作用。将浸泡过内毒素的棉线植入大鼠股动脉腹侧的外膜，导致白细胞仅在血管腹侧的一半迁移到血管壁。白细胞从管腔侧和外膜侧迁移，由中性粒细胞和单核细胞组成。植入后1周首次观察到富含平滑肌细胞的内膜病变局限于血管腹侧的一半。病变在第6周时仍局限于血管壁的腹侧一半。当用 dexamethasone 治疗抑制白细胞迁移到血管壁时，病变发展未发生。这些结果表明，白细胞可刺激平滑肌细胞迁移到内膜并导致内膜病变形成。
