抗凝血酶III浓缩物在休克和弥散性血管内凝血中的替代疗法。

Substitution therapy with an antithrombin III concentrate in shock and DIC.

作者信息

Blauhut B, Necek S, Vinazzer H, Bergmann H

出版信息

Thromb Res. 1982 Aug 1;27(3):271-8. doi: 10.1016/0049-3848(82)90074-3.

Abstract

In 15 patients admitted to the Intensive Care Unit for shock and with signs of DIC, Antithrombin III (AT III) was substituted. Immediately after the first blood sampling, 1,000 units of AT III was given. This was followed by 500 units AT III after 24 h and after 48 h. A continuous dose of heparin of between 250 and 500 I.U./h was simultaneously given. The following results were obtained: The activity of AT III on admission of 63 +/- 19% increased to 83 +/- 17% 30 min after the initial substitution. There was a clear difference between the recovery of the substituted AT III in acute DIC and in patients in a steady state. AT III recovered in circulation was 47 +/- 15% in the former group but 83 +/- 16% in the latter cases. One unit of AT III per kg body weight increased AT III activity in circulation by 1% in acute DIC but by 1.8% in a steady state. The average half life of the substituted AT III was 4.4 +/- 1.6 h in acute DIC and was 20.2 +/- 4.1 h when the patients were in a steady state.

摘要

15名因休克入住重症监护病房且有弥散性血管内凝血（DIC）迹象的患者接受了抗凝血酶III（AT III）替代治疗。首次采血后立即给予1000单位的AT III。24小时和48小时后分别再给予500单位的AT III。同时给予250至500国际单位/小时的持续肝素剂量。获得了以下结果：入院时AT III活性为63±19%，初始替代后30分钟增加至83±17%。急性DIC患者与病情稳定患者替代的AT III恢复情况存在明显差异。前一组循环中恢复的AT III为47±15%，而后一组为83±16%。每千克体重1单位的AT III在急性DIC中使循环中的AT III活性增加1%，而在病情稳定时增加1.8%。替代的AT III在急性DIC中的平均半衰期为4.4±1.6小时，患者病情稳定时为20.2±4.1小时。