[Studies on influence of detergents on human serum albumin using temperature-perturbation difference spectrophotometry].

The temperature-perturbation difference spectra (TPDS) of human serum albumin (NSA) were studied after incubation with different synthetic detergents--anionic, cationic, amphoteric, nonionogenic--in various molar ratios. It is shown that the detergents studied have a different effect on the perturbation of tyrosine residua spectra. Under these conditions the rigidity of their environment depending on the nature and concentration of the mentioned detergents is supposed to change.