1-methyl and 1-benzyl derivatives of tetrahydroisoquinoline inhibit 5-hydroxytryptamine uptake by human blood platelets.

The effect of 1-methyl (salsoline, salsolidine) and 1-benzyl (papaverine) derivatives of tetrahydroisoquinoline (TIQ) on 5-hydroxytryptamine (5-HT) uptake by human blood platelets was studied. The drugs tested inhibited 5-HT (3 X 10(-6)M 5 min incubation) uptake by 30--60 % at 10(-4)M concentration and by 20--25 % at 10(-5)M concentration.