Kanaide H, Takeshita A, Nakamura M
Am Heart J. 1982 Nov;104(5 Pt 1):1039-45. doi: 10.1016/0002-8703(82)90438-0.
Sixteen patients with Takayasu's aortitis were studied to evaluate the significance of coagulopathy in the etiology. In the initial stage of the disease (three cases) characterized by severe inflammatory symptoms with aortic lesions localized in the thoracic portion, marked hyperfibrinogenemia, and hypofibrinolytic activity of the plasma were observed. In the intermediate stage (five cases) characterized by moderate inflammation and aortic lesions expanded into thoracic and abdominal portions, hyperfibrinogenemia and hypofibrinolytic activity were also seen; in three of these cases, hypercoagulability was evident because of the presence of fibrinogen derivatives having gamma-gamma-diads in the plasma. When the inflammation subsided after the establishment of aortic lesions, the end-stage (eight cases), hyperfibrinolytic activity with normal plasma fibrinogen was observed. It is suggested that hypercoagulability may be in response to the arterial disease and may possibly play a part in the development of this disorder.
对16例大动脉炎患者进行了研究，以评估凝血功能障碍在病因学中的意义。在疾病的初始阶段（3例），其特征为严重炎症症状，主动脉病变局限于胸部，观察到明显的高纤维蛋白原血症和血浆纤溶活性降低。在中间阶段（5例），其特征为中度炎症，主动脉病变扩展至胸部和腹部，也可见高纤维蛋白原血症和纤溶活性降低；在其中3例中，由于血浆中存在具有γ-γ二聚体的纤维蛋白原衍生物，高凝状态明显。当主动脉病变形成后炎症消退时，进入终末期（8例），观察到血浆纤维蛋白原正常但纤溶活性增强。提示高凝状态可能是对动脉疾病的反应，可能在该疾病的发展中起作用。
