Analytical goals and the College of American Pathologists.

Classifications of measurement procedures rank routine control and laboratory simulation as the most difficult measurements. Their use in laboratory medicine has led to the development of a science whose purpose is to quantitate various characteristics of laboratory performance. The College of American Pathologists application of the science takes the form of its quality assurance programs, notably the Survey Programs. Until recently, however, the concern for reduction of analytical error and the engrafted aspects of regulation have diverted attention from the major purpose of the programs: the establishment and achievement of analytical goals based on clinical utility. The College is working toward these ends, and its work is based on the following principles: (1) formulation of analytical goals is the responsibility of the profession; (2) the analytical goals are a scientific composite of total analytical error, biologic variation, and medical judgement; (3) analytical goals must be adjustable to accommodate laboratory and clinical advances.