Kafka M T
Department of Pathology, St Luke's Regional Medical Center, Sioux City, IA 51104.
Arch Pathol Lab Med. 1988 Apr;112(4):449-53.
Estimates of instrument-specific analytical performance for measurement of four chemistry analytes (calcium, cholesterol, creatinine, and glucose) were derived from 21 quality control programs that utilized the College of American Pathologists Quality Assurance Service and from 12 College of American Pathologists Comprehensive Chemistry Survey sets. The quality control-derived estimates of analytical bias were larger and level-dependent when compared with the survey results. Possible explanations for these differences include "matrix effects" due to glycol stabilization of the control materials studied and analyst bias when testing survey specimens. A number of instruments from the Quality Assurance Service pools failed to meet the allowable analytical error goals for calcium and creatinine that serve as the basis for the "fixed limits" evaluation criteria of the survey program. The methods for glucose analysis met the prescribed evaluation limits. Cholesterol analyses need significant improvement to meet the analytical requirements of long-term testing of individuals.
对四种化学分析物（钙、胆固醇、肌酐和葡萄糖）测量的特定仪器分析性能估计值，来自21个使用美国病理学家学会质量保证服务的质量控制程序，以及12套美国病理学家学会综合化学调查数据集。与调查结果相比，质量控制得出的分析偏差估计值更大且与水平有关。这些差异的可能解释包括所研究的对照材料因乙二醇稳定化产生的“基质效应”，以及检测调查样本时分析人员的偏差。质量保证服务库中的许多仪器未能达到作为调查计划“固定限值”评估标准基础的钙和肌酐的允许分析误差目标。葡萄糖分析方法达到了规定的评估限值。胆固醇分析需要大幅改进，以满足个体长期检测的分析要求。
