Biggar R J, Gail M H, Banks R B, Neequaye J, Nkrumah F K
Am J Epidemiol. 1982 Oct;116(4):668-77. doi: 10.1093/oxfordjournals.aje.a113449.
The frequency of Burkitt's lymphoma peaks in children six to nine years of age and is twice as high in males as in females. To determine if age or sex had any relationship to outcome of therapy, the authors examined the experience of 387 patients treated for Burkitt's lymphoma at the Burkitt Tumor Project, Accra, Ghana, between 1966 and 1978. No age or sex relationship could be demonstrated with overall survival. However, among children without central nervous system disease who achieved an initial remission, the relapse rates were higher for those diagnosed initially in the age interval 6-9 years than for those diagnosed at younger or older ages. This pattern was seen for each stage of the disease as well as overall. Sex did not influence relapse rate. The relationship of these findings to the Epstein-Barr virus and malaria, both suspected factors in the etiology of this disease, is discussed, but neither appears to explain our results.
伯基特淋巴瘤的发病频率在6至9岁儿童中达到峰值，男性发病率是女性的两倍。为了确定年龄或性别与治疗结果是否存在任何关联，作者研究了1966年至1978年间在加纳阿克拉的伯基特肿瘤项目中接受伯基特淋巴瘤治疗的387例患者的情况。在总生存率方面，未发现年龄或性别与生存率之间存在关联。然而，在没有中枢神经系统疾病且最初获得缓解的儿童中，最初在6至9岁年龄段被诊断出的患者复发率高于较年轻或较年长时被诊断出的患者。这种模式在疾病的各个阶段以及总体情况中均可见。性别不影响复发率。本文讨论了这些发现与爱泼斯坦-巴尔病毒和疟疾的关系，这两者都是该疾病病因中被怀疑的因素，但似乎都无法解释我们的结果。
