巴西东南部爱泼斯坦-巴尔病毒相关儿童伯基特淋巴瘤的临床和人口统计学特征：来自中等风险地区的流行病学见解

Clinical and demographic characteristics of Epstein-Barr virus-associated childhood Burkitt's lymphoma in Southeastern Brazil: epidemiological insights from an intermediate risk region.

作者信息

Hassan Rocio, Klumb Claudete Esteves, Felisbino Fabricio E, Guiretti Deisy M, White Lídia R, Stefanoff Claudio Gustavo, Barros Mario Henrique M, Seuánez Héctor N, Zalcberg Ilana R

机构信息

Instituto Nacional de Câncer, INCA-Bone Marrow Transplantation Centre (CEMO). Praça da Cruz Vermelha 23, 6th floor, 20230-130, Rio de Janeiro, RJ, Brazil.

出版信息

Haematologica. 2008 May;93(5):780-3. doi: 10.3324/haematol.12424. Epub 2008 Mar 26.

DOI:10.3324/haematol.12424

PMID:18367488

Abstract

We studied a group of 54 children with Burkitt's lymphoma from Southeastern Brazil, where epidemiological status of Burkitt's lymphoma is poorly understood. Epstein-Barr virus association showed an intermediate frequency (~60%) between endemic and sporadic subtypes. Median age was five years. Epstein-Barr virus infection was significantly associated to low age (Epstein-Barr virus(+) four years vs. Epstein-Barr virus(-) eight years). Sex ratio (M:F) was 2:1, with a significantly higher number of males in old age classes. Young age at diagnosis and excess of males at older ages, as well as a causal relationship between low age, epstein-barr virus and Burkitt's lymphoma risk, may characterize Burkitt's lymphoma in Brazil.

摘要

我们研究了来自巴西东南部的54名伯基特淋巴瘤患儿，该地区对伯基特淋巴瘤的流行病学状况了解甚少。爱泼斯坦-巴尔病毒关联显示，其在地方性和散发性亚型之间的频率处于中等水平（约60%）。中位年龄为5岁。爱泼斯坦-巴尔病毒感染与低龄显著相关（爱泼斯坦-巴尔病毒阳性患儿为4岁，阴性患儿为8岁）。性别比（男：女）为2：1，老年组男性数量显著更多。诊断时年龄小以及老年男性过多，再加上低龄、爱泼斯坦-巴尔病毒与伯基特淋巴瘤风险之间存在因果关系，可能是巴西伯基特淋巴瘤的特征。