新生儿坏死性小肠结肠炎：八十年代的新思考

Neonatal necrotising enterocolitis: new thoughts for the 'eighties.

作者信息

Wijesinha S S

出版信息

Ann R Coll Surg Engl. 1982 Nov;64(6):406-9.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2494087/

Abstract

Neonatal necrotising enterocolitis has become one of the commonest abdominal emergencies seen by the paediatric surgeon. Historical aspects of the condition and current ideas regarding its pathogenesis are described. An immunological basis for the disease is suggested by its relative rarity in regions where breast feeding is widespread and by recent research work on the intestinal immune system. A new theory about the aetiology of the disease, stressing not a specific pathogen but rather the concept of defective intestinal immunity, is postulated.

摘要

新生儿坏死性小肠结肠炎已成为儿科外科医生所见到的最常见的腹部急症之一。本文描述了该病症的历史背景及当前关于其发病机制的观点。母乳喂养普遍的地区该病相对少见，以及近期关于肠道免疫系统的研究工作提示了该病的免疫学基础。本文提出了一种关于该病病因的新理论，该理论强调的不是特定病原体，而是肠道免疫缺陷的概念。

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