Shiner M
Pediatr Med Chir. 1982 Jul-Aug;4(4):359-64.
The infant acquires immunological competence in the neonatal period through the passage of antigens from the enteric lumen through gut-associated lymphoid tissues, principally the Peyer's patches and the appendix. Immune deficient mechanisms may be involved in several gastrointestinal diseases manifesting in the neonatal period as well as throughout childhood. Principally among these are neonatal necrotising enterocolitis, atopy and food intolerances, coeliac disease, cow's milk protein intolerance, diarrhoea associated with hypogammaglobulinaemia, malnutrition and inflammatory bowel disease. The mechanism whereby immune reactions are involved in the pathogenesis of these diseases is discussed.
婴儿在新生儿期通过抗原从肠腔穿过肠道相关淋巴组织（主要是派尔集合淋巴结和阑尾）获得免疫能力。免疫缺陷机制可能与新生儿期以及整个儿童期出现的几种胃肠道疾病有关。其中主要包括新生儿坏死性小肠结肠炎、特应性和食物不耐受、乳糜泻、牛奶蛋白不耐受、与低丙种球蛋白血症相关的腹泻、营养不良和炎症性肠病。本文讨论了免疫反应参与这些疾病发病机制的方式。
