Carmel R
Arch Intern Med. 1982 Nov;142(12):2206-7. doi: 10.1001/archinte.142.12.2206.
Classic pernicious anemia with abnormal Schilling test results developed in a previously described vegan patient who had coexisting subtle cobalamin malabsorption (demonstrable by abnormal ovalbumin-cobalamin absorption test results but normal Schilling test results). This suggests that the ovalbumin-cobalamin absorption test or a modified version may serve as a prodromal phenomenon to identify patients at risk for developing pernicious anemia. The patient's transformation was also accompanied by the appearance of serum anti-intrinsic factor antibody. A modified assay retrospectively detected this antibody a year earlier than did the standard assay, indicating that such modification enhances the sensitivity of this useful test.
一名先前描述过的纯素食患者出现了经典型恶性贫血，其希林试验结果异常，该患者同时存在轻微的钴胺素吸收不良（通过异常的卵清蛋白 - 钴胺素吸收试验结果可证明，但希林试验结果正常）。这表明卵清蛋白 - 钴胺素吸收试验或其改良版本可能作为一种前驱现象，用于识别有患恶性贫血风险的患者。该患者的病情转变还伴随着血清抗内因子抗体的出现。一种改良检测方法比标准检测方法提前一年回顾性地检测到了这种抗体，表明这种改良提高了这项有用检测的灵敏度。
