Cibis G W, Tripathi R C, Tripathi B J, Harris D J
Arch Ophthalmol. 1982 Nov;100(11):1795-9. doi: 10.1001/archopht.1982.01030040775013.
Bilateral corneal keloids in a boy wih Lowe's syndrome were examined by conventional light and electron microscopy. There were no signs of perforating corneal trauma or iridocorneal incarceration in either eye. The corneal keloids consisted of haphazardly arranged bundles of collagen fibers, fibroblasts, and fenestrated blood vessels. The anterior region of the keloids showed signs of active progression and epithelial epidermalization. The etiology of keloids in Lowe's syndrome remains obscure. Considerations include excessive local delivery of amino acids and unknown noxious substances through the leak corneal vessels, seepage of similar substances across the defective blood-aqueous barrier and the decompensated endothelium, repeated external trauma with associated inflammation, phenytoin (Dilantin) therapy, and congenital predisposition. No data are available on the management of the progressive course of corneal keloids. Possible empirical regimens include local excision, pressure therapy, topical corticosteroids, and cromolyn sodium.
对一名患有劳氏综合征的男孩的双侧角膜瘢痕疙瘩进行了传统光学显微镜和电子显微镜检查。两只眼睛均未发现角膜穿孔外伤或虹膜角膜嵌顿的迹象。角膜瘢痕疙瘩由杂乱排列的胶原纤维束、成纤维细胞和有窗孔的血管组成。瘢痕疙瘩的前部显示出活跃进展和上皮表皮化的迹象。劳氏综合征中瘢痕疙瘩的病因仍不清楚。考虑因素包括通过渗漏的角膜血管局部过量输送氨基酸和未知有害物质、类似物质通过有缺陷的血-房水屏障和失代偿的内皮渗漏、反复的外部创伤伴相关炎症、苯妥英钠（地伦丁）治疗以及先天性易感性。目前尚无关于角膜瘢痕疙瘩进行性病程管理的数据。可能的经验性治疗方案包括局部切除、压力疗法、局部使用皮质类固醇和色甘酸钠。
