Whitsett S F, Lubar J F, Holder G S, Pamplin W E, Shabsin H S
Biofeedback Self Regul. 1982 Jun;7(2):193-209. doi: 10.1007/BF00998783.
The sleep EEGs of eight medically refractory epileptic patients were examined as part of a double-blind, ABA crossover study designed to determine the effectiveness of EEG biofeedback for the control of seizures. The patients were initially reinforced for one of three EEG criteria recorded from electrodes placed over sensorimotor cortex: (a) suppression of 3- to 7-Hz activity, (b) enhancement of 12- to 15-Hz activity, or (c) simultaneous suppression of 3- to 7-Hz and enhancement of 11- to 19-Hz activity. Reinforcement contingencies were reversed during the second or B phase, and then reinstated in their original form during the final A' phase. All-night polysomnographic recordings were obtained at the end of each conditioning phase and were subjected to both visual and computer-based power spectral analyses. Four of the patients showed changes in their nocturnal paroxysmal activity that were either partially or totally consistent with the ABA' contingencies of the study. The spectral data proved difficult to interpret, though two trends emerged from the analyses. Decreases in nocturnal 4- to 7-Hz activity were correlated with decreases in seizure activity, and increases in 8- to 11-Hz activity were correlated with decreases in seizure activity. These findings were shown to strengthen the hypothesis that EEG biofeedback may produce changes in the sleep EEG that are related to seizure incidence.
作为一项双盲ABA交叉研究的一部分，对8名药物难治性癫痫患者的睡眠脑电图进行了检查，该研究旨在确定脑电图生物反馈对癫痫控制的有效性。最初，根据放置在感觉运动皮层上方电极记录的三种脑电图标准之一对患者进行强化：（a）抑制3至7赫兹的活动，（b）增强12至15赫兹的活动，或（c）同时抑制3至7赫兹并增强11至19赫兹的活动。在第二阶段或B阶段，强化条件发生逆转，然后在最后的A'阶段恢复为原来的形式。在每个调节阶段结束时进行整夜多导睡眠图记录，并对其进行视觉和基于计算机的功率谱分析。4名患者夜间阵发性活动的变化部分或完全与研究的ABA'条件一致。光谱数据难以解释，不过分析中出现了两个趋势。夜间4至7赫兹活动的减少与癫痫活动的减少相关，8至11赫兹活动的增加与癫痫活动的减少相关。这些发现表明强化了脑电图生物反馈可能会使睡眠脑电图产生与癫痫发作发生率相关变化的假设。
