Yousef I M, Tuchweber B
Biol Neonate. 1982;42(3-4):105-12. doi: 10.1159/000241583.
Bile acid (BA) metabolism was studied in the intestine, liver and plasma of rats at 0-1 day (neonates); 14 days (preweaning); 22 days (weaning) and 60 days (young adults) of age, as well as in the maternal tissues. In the intestine, total BA content (mumol/100 g body weight) decreased during neonatal life and reached maternal levels at 60 days. In the liver, BA increased up to 14 days and then decreased at 22 and 60 days of age, but these concentrations were higher than those found in the neonate and the mother. The serum concentrations in 14- and 22-day-old rats were more than 30 times higher than in the newborns. At 60 days, serum BA content was still twice that of the mother. BA composition in the intestine and the liver showed a reduction in 12 alpha-hydroxylated BA associated with an increase in chenodeoxycholic acid and 6 beta-hydroxylated BA during neonatal life. These data indicate an increased synthesis of chenodeoxycholic and 6 beta-hydroxylated BA after birth. It further suggests a possible defect in excretory mechanisms in neonatal life.
研究了0至1日龄（新生大鼠）、14日龄（断奶前）、22日龄（断奶）和60日龄（年轻成年大鼠）大鼠以及母体组织肠道、肝脏和血浆中的胆汁酸（BA）代谢。在肠道中，总BA含量（μmol/100 g体重）在新生期降低，并在60日龄时达到母体水平。在肝脏中，BA在14日龄前升高，然后在22日龄和60日龄时降低，但这些浓度高于新生大鼠和母体中的浓度。14日龄和22日龄大鼠的血清浓度比新生大鼠高30倍以上。在60日龄时，血清BA含量仍为母体的两倍。在新生期，肠道和肝脏中的BA组成显示12α-羟基化BA减少，同时鹅去氧胆酸和6β-羟基化BA增加。这些数据表明出生后鹅去氧胆酸和6β-羟基化BA的合成增加。这进一步表明新生期排泄机制可能存在缺陷。
