Hassan A S, Yunker R L, Subbiah M T
Biol Neonate. 1982;41(3-4):110-4. doi: 10.1159/000241538.
Effect of neonatal thyroidectomy, adrenalectomy and streptozotocin-induced diabetes in rats on the bile acid pool size and composition at weaning was examined. Adrenalectomy caused a significant (p less than 0.05) decrease in the total bile acid pool with significant reductions (p less than 0.05) in both cholic and chenodeoxycholic acids. Thyroidectomy on the other hand caused a specific decrease (p less than 0.05) in chenodeoxycholic acid pool. Streptozotocin-induced diabetes caused (a) a decrease (p less than 0.05) in total bile acid pool with a significant (p less than 0.05) reduction in chenodeoxycholic acid, and (b) an increase in plasma cholesterol levels.
研究了新生大鼠甲状腺切除、肾上腺切除及链脲佐菌素诱导的糖尿病对断奶时胆汁酸池大小和组成的影响。肾上腺切除导致总胆汁酸池显著减少（p<0.05），胆酸和鹅去氧胆酸均显著降低（p<0.05）。另一方面，甲状腺切除导致鹅去氧胆酸池特异性减少（p<0.05）。链脲佐菌素诱导的糖尿病导致：（a）总胆汁酸池减少（p<0.05），鹅去氧胆酸显著降低（p<0.05）；（b）血浆胆固醇水平升高。
