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大鼠小脑-橄榄体投射:放射自显影研究

Cerebello-olivary projections in the rat. An autoradiographic study.

作者信息

Anguat P, Cicirata F

出版信息

Brain Behav Evol. 1982;21(1):24-33. doi: 10.1159/000121612.

DOI:10.1159/000121612
PMID:7139259
Abstract

Projections of deep cerebellar nuclei onto the inferior olive have been studied using autoradiographic methods in adult Wistar rats: the distribution of the labelling consequent to injections of tritiated amino acids, limited to one of the cerebellar nuclei, was mapped in the inferior olive. Each of the four cerebellar deep nuclei project to a specific region of the contralateral inferior olive. Only caudal parts of the medial cerebellar nucleus send fibres to the olive, where they reach the caudal half of the medial accessory olive. Anterior and posterior interposed nuclei project to the dorsal accessory and the rostral half to the medial accessory olives, respectively. The lateral, or dentate nucleus projects to the principal olive. This projection discloses a clear-cut topological arrangement. Besides, a few dentato-olivary fibres recross the midline in the interolivary region and end in areas of the ipsilateral principal olive symmetric to the contralateral projection. These results are discussed with special consideration to comparative anatomy.

摘要

利用放射自显影方法,在成年Wistar大鼠中研究了小脑深部核团向下橄榄核的投射:将注射了氚化氨基酸(仅限于一个小脑核团)后产生的标记分布绘制在下橄榄核中。四个小脑深部核团中的每一个都投射到对侧下橄榄核的特定区域。只有小脑内侧核的尾部向橄榄核发送纤维,这些纤维到达内侧副橄榄核的后半部分。前间位核和后间位核分别投射到背侧副橄榄核和内侧副橄榄核的前半部分。外侧核,即齿状核投射到主橄榄核。这种投射显示出一种清晰的拓扑排列。此外,一些齿状核-橄榄核纤维在橄榄核间区域交叉中线,并终止于同侧主橄榄核中与对侧投射对称的区域。将结合比较解剖学的特殊考虑对这些结果进行讨论。

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