急性氯化汞中毒所致横纹肌溶解症与肾衰竭

Rhabdomyolysis and renal failure in acute mercuric chloride poisoning.

作者信息

Chugh K S, Singhal P C, Uberoi H S

出版信息

Med J Aust. 1978 Jul 29;2(3):125-6. doi: 10.5694/j.1326-5377.1978.tb131407.x.

DOI:10.5694/j.1326-5377.1978.tb131407.x

Abstract

A case of acute renal failure after mercuric chloride poisoning is reported. Laboratory data revealed markedly elevated serum concentrations of aldolase and creatine phosphokinase, and the presence of pigment granular casts and myoglobin in the urine. The patient went into a diuretic phase after 12 days of oliguria and renal function returned to normal during the next 10 days. Besides direct nephrotoxicity, the contributory role of rhabdomyolysis in the pathogenesis of renal failure after mercuric chloride poisoning, has been stressed.

摘要

报告了一例氯化汞中毒后急性肾衰竭的病例。实验室数据显示醛缩酶和肌酸磷酸激酶的血清浓度显著升高，且尿液中存在色素颗粒管型和肌红蛋白。患者少尿12天后进入利尿期，随后10天内肾功能恢复正常。除直接肾毒性外，还强调了横纹肌溶解在氯化汞中毒后肾衰竭发病机制中的作用。