Magee D A, Sweet P T, Holland A J
Can Anaesth Soc J. 1982 Nov;29(6):577-80. doi: 10.1007/BF03007744.
Pretreatment with small (10 mg) doses of succinylcholine ("self-taming") decreases the incidence of muscle fasciculations following succinylcholine administration and may decrease the incidence of other unwanted effects. This study was designed to assess the cardiac effects of such self-taming and to assess the degree of protection afforded against bradydysrhythmias following subsequent succinylcholine administration. Sixty patients were studied and allocated randomly to three groups of twenty. Each group was assigned a different form of pretreatment. Patients in group I received 10 mg of succinylcholine immediately after induction. Patients in group II were treated with d-tubocurarine 0.04k mg . kg-1 three minutes before induction. Patients in group III received no pretreatment. All patients were induced with thiopentone 4 mg . kg-1 followed by succinylcholine 1 mg . kg-1 45 seconds later. A second dose of succinylcholine 1 mg . kg-1 was administered to the patients in the two pretreatment groups between four and five minutes after the first dose of succinylcholine. Following both the first and second doses of succinylcholine patients in the self-taming group showed a significantly greater incidence of bradydysrhythmias when compared to the other two groups. It is concluded that the use of a self-taming technique is potentially hazardous, and that it does not confer protection against repeated succinylcholine administration.
用小剂量（10毫克）琥珀酰胆碱进行预处理（“自我驯服”）可降低琥珀酰胆碱给药后肌肉震颤的发生率，并可能降低其他不良效应的发生率。本研究旨在评估这种自我驯服的心脏效应，并评估在随后给予琥珀酰胆碱后对缓慢性心律失常的保护程度。对60名患者进行了研究，并随机分为三组，每组20人。每组被分配不同形式的预处理。第一组患者在诱导后立即接受10毫克琥珀酰胆碱。第二组患者在诱导前三分钟接受0.04毫克/千克的筒箭毒碱治疗。第三组患者未接受预处理。所有患者均用4毫克/千克的硫喷妥钠诱导，45秒后给予1毫克/千克的琥珀酰胆碱。在第一剂琥珀酰胆碱给药后4至5分钟之间，对两个预处理组的患者给予第二剂1毫克/千克的琥珀酰胆碱。与其他两组相比，自我驯服组患者在第一剂和第二剂琥珀酰胆碱给药后出现缓慢性心律失常的发生率显著更高。得出的结论是，使用自我驯服技术有潜在危险，并且它不能对重复给予琥珀酰胆碱提供保护。
