Viby-Mogensen J, Wisborg K, Sørensen O
Br J Anaesth. 1980 Nov;52(11):1137-42. doi: 10.1093/bja/52.11.1137.
Eighty healthy patients were randomly allocated to four groups. Atropine 0.01 mg kg-1 i.v. (group I), gallamine 0.3 mg kg-1 i.v. (group II), atropine 0.01 mg kg-1 i.m. and gallamine 0.3 mg kg-1 i.v. (group III), or atropine 0.01 mg kg-1 i.v. and gallamine 0.3 mg kg-1 i.v. (group IV) were given before operation. After induction of anesthesia with thiopentone, suxamethonium 1 mg kg-1 was given i.v. The lungs were ventilated with halothane in nitrous oxide in oxygen. Five minutes later the same dose of suxamethonium was repeated. E.c.g. was monitored continuously. No serious bradycardia was observed following a second injection of suxamethonium in any group. The results suggest that thiopentone protects against suxamethonium-induced bradycardia during halothane anaesthesia.
80名健康患者被随机分为四组。术前分别给予：静脉注射0.01mg/kg阿托品（第一组）、静脉注射0.3mg/kg加拉明（第二组）、肌肉注射0.01mg/kg阿托品及静脉注射0.3mg/kg加拉明（第三组）、静脉注射0.01mg/kg阿托品及静脉注射0.3mg/kg加拉明（第四组）。用硫喷妥钠诱导麻醉后，静脉注射1mg/kg琥珀酰胆碱。在氧化亚氮-氧气中用氟烷对肺部进行通气。5分钟后重复给予相同剂量的琥珀酰胆碱。持续监测心电图。在任何一组中，第二次注射琥珀酰胆碱后均未观察到严重心动过缓。结果表明，在氟烷麻醉期间，硫喷妥钠可预防琥珀酰胆碱诱导的心动过缓。
