Kwan P W, Merk F B, Leav I, Ofner P
Cell Tissue Res. 1982;226(3):689-93. doi: 10.1007/BF00214795.
Glandular cells in the prostate of the intact, adult dog contain numerous, large secretory granules that are released by exocytosis. Following hypophysectomy or castration, the glandular epithelium atrophies and the secretory granules degenerate and eventually disappear. Pharmacologic doses of estradiol-17 beta 17-cyclopentylpropionate cause the regressed glandular cells to synthesize a new population of smaller granules that are also released by exocytosis, even though estrogen is known to inhibit fluid secretion by the canine prostate. Thus, the mechanisms involved in prostatic synthesis and exocytosis of secretory granules are independent of those regulating fluid secretion and are operative in the absence of androgen or pituitary hormones.
成年未阉割犬前列腺中的腺细胞含有大量大的分泌颗粒，这些颗粒通过胞吐作用释放。垂体切除或阉割后，腺上皮萎缩，分泌颗粒退化并最终消失。药理剂量的17β-雌二醇17-环戊丙酸酯可使退化的腺细胞合成一批新的较小颗粒，这些颗粒也通过胞吐作用释放，尽管已知雌激素会抑制犬前列腺的液体分泌。因此，前列腺分泌颗粒的合成和胞吐作用所涉及的机制独立于调节液体分泌的机制，并且在没有雄激素或垂体激素的情况下也起作用。
