邻苯二甲酸二（2-乙基己基）酯对小鼠的致畸性/胚胎毒性。
Teratogenicity/fetotoxicity of DEHP in mice.
作者信息
Tomita I, Nakamura Y, Yagi Y, Tutikawa K
出版信息
Environ Health Perspect. 1982 Nov;45:71-5. doi: 10.1289/ehp.824571.
The embryonic/fetotoxic effects of DEHP on pregnant mice (ddY-Slc female x CBA male) were studied. DEHP was administered orally in dosages of 0.05 ml/kg to 30.0 mg/kg on day 6, 7, 8, 9 or 10 of gestation. A single administration of DEHP over 0.1 ml/kg (1/300 of LD50) on day 7 of gestation decreased the numbers and the body weight of living fetuses, whereas no significant changes in the numbers of living fetuses (with no gross and skeletal abnormalities) were observed compared with those of the control group, when 0.05 ml/kg (1/600 of LD50) of DEHP was administered. The fetotoxicity (fetal death) was dose dependent. The LD50 and the nonfetolethal maximum dosage of DEHP in its single, oral administration was 592 mg/kg and 64 mg/kg, respectively. The latter value is much higher than an estimated DEHP intake from commercial foodstuffs in men, which is approximately 0.03 mg/kg/day.
研究了邻苯二甲酸二（2-乙基己基）酯（DEHP）对怀孕小鼠（ddY-Slc雌性×CBA雄性）的胚胎/胎儿毒性作用。在妊娠第6、7、8、9或10天，以0.05 ml/kg至30.0 mg/kg的剂量口服给予DEHP。在妊娠第7天单次给予超过0.1 ml/kg（LD50的1/300）的DEHP会减少存活胎儿的数量和体重，而当给予0.05 ml/kg（LD50的1/600）的DEHP时，与对照组相比，未观察到存活胎儿数量（无明显肉眼和骨骼异常）有显著变化。胎儿毒性（胎儿死亡）呈剂量依赖性。DEHP单次口服给药的LD50和非致死最大剂量分别为592 mg/kg和64 mg/kg。后一数值远高于男性从商业食品中估计的DEHP摄入量，约为0.03 mg/kg/天。
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