Rosenhall L
Eur J Respir Dis. 1982 Sep;63(5):410-9.
In 504 patients with asthma or rhinitis 1,868 oral challenge tests with analgesics, preservatives and food colorants were performed. Sodium benzoate and other benzoic compounds, as well as tartrazine and other azo dyes, were found to give similar but milder adverse reactions than acetylsalicylic acid. No patients reacted to potassium sorbate, another preservative, or to Patent Blue, which is not an azo dye. Intolerance was demonstrated most frequently in patients with a history of adverse reactions to analgesics or food, but also in 6% of patients investigated for other reasons. There are obvious risks for false positive or false negative results with a challenge test. Examples of these are given. The need for repeated tests and the clinical importance of all reproducible challenge reactions is stressed.
对504例哮喘或鼻炎患者进行了1868次口服镇痛药、防腐剂和食用色素激发试验。发现苯甲酸钠和其他苯甲酸化合物以及酒石黄和其他偶氮染料引起的不良反应与乙酰水杨酸相似，但程度较轻。没有患者对另一种防腐剂山梨酸钾或非偶氮染料专利蓝产生反应。不耐受现象在有镇痛药或食物不良反应史的患者中最为常见，但在因其他原因接受调查的患者中也有6%出现。激发试验存在假阳性或假阴性结果的明显风险。文中给出了这些情况的例子。强调了重复试验的必要性以及所有可重复激发反应的临床重要性。
