3-苄基-1,2-苯并异噻唑化合物的生物学性质。
Biological properties of 3-benzyl-1,2-benzisothiazole compounds.
作者信息
Vitali T, Impicciatore M, Plazzi P V
出版信息
Farmaco Sci. 1982 Oct;37(10):674-7.
PMID:7140968
Abstract
By reaction of 3-chloro-1,2-benzisothiazole with phenylacetonitrile, 3-benzyl-1,2-benzisothiazole derivatives can be obtained. These compounds seem to mimic the benzylisoquinoline structure so they can exhibit spasmolytic activities. Both antimuscarinic and direct muscle-relaxant properties have been found with N,N-dimethyl-3-phenyl-3-(1,2-benzisothiazol-3-yl) propylamine hydrochloride.
摘要
通过3-氯-1,2-苯并异噻唑与苯乙腈反应，可以得到3-苄基-1,2-苯并异噻唑衍生物。这些化合物似乎模仿了苄基异喹啉结构，因此它们可以表现出解痉活性。盐酸N,N-二甲基-3-苯基-3-(1,2-苯并异噻唑-3-基)丙胺同时具有抗毒蕈碱和直接肌肉松弛特性。
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