Molina E, Amoretti L, Zappia L, Michelini G F
Ateneo Parmense Acta Biomed. 1977;48(1):5-12.
A report is given on the spasmolytic effect of two benzisothiazolcarboxyamides (compound A and compound B). These drugs were able to inhibit the stimulant action of histamine on human isolated myometrium. The potency of the two compounds exceeded by ten times that of ritodrine (a beta adrenergic stimulant), the efficacy was slightly higher (20-30%) than that of papaverine. This pharmacological effect is discussed on the light of the spectrum of activites of the benzisothiazolcarboxyamidic compounds.
给出了关于两种苯并异噻唑甲酰胺（化合物A和化合物B）解痉作用的报告。这些药物能够抑制组胺对人离体子宫肌层的刺激作用。这两种化合物的效力比利托君（一种β肾上腺素能兴奋剂）高出十倍，疗效比罂粟碱略高（20 - 30%）。根据苯并异噻唑甲酰胺类化合物的活性谱对这种药理作用进行了讨论。
