[1,2-苯并异噻唑化合物的生物学特性。N-(环己基氨基乙基)-1,2-苯并异噻唑-3-甲酰胺对人子宫肌层体外片段的解痉作用]
[Biological properties of 1,2-benzisothiazole compounds. Spasmolytic effect of N-(cyclohexylaminoethyl)-1,2-benzisothiazole-3-carboxyamides benzene-substituted on segments of human myometrium in virto].
作者信息
Molina E, Amoretti L, Zappia L, Michelini G F
出版信息
Ateneo Parmense Acta Biomed. 1977;48(1):5-12.
PMID:558765
Abstract
A report is given on the spasmolytic effect of two benzisothiazolcarboxyamides (compound A and compound B). These drugs were able to inhibit the stimulant action of histamine on human isolated myometrium. The potency of the two compounds exceeded by ten times that of ritodrine (a beta adrenergic stimulant), the efficacy was slightly higher (20-30%) than that of papaverine. This pharmacological effect is discussed on the light of the spectrum of activites of the benzisothiazolcarboxyamidic compounds.
摘要
给出了关于两种苯并异噻唑甲酰胺（化合物A和化合物B）解痉作用的报告。这些药物能够抑制组胺对人离体子宫肌层的刺激作用。这两种化合物的效力比利托君（一种β肾上腺素能兴奋剂）高出十倍，疗效比罂粟碱略高（20 - 30%）。根据苯并异噻唑甲酰胺类化合物的活性谱对这种药理作用进行了讨论。
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