Cagliero E, Porta M, Cousins S, Kohner E M
Haemostasis. 1982;12(3):293-9. doi: 10.1159/000214686.
Platelet volume was measured in 30 healthy controls and 87 diabetic patients, the latter subdivided according to the absence, presence and severity of retinopathy, to investigate if platelet size is related to microangiopathy. The platelet volume of the whole diabetic population was increased (p less than 0.05) due to a higher percentage of large elements (p less than 0.05). The patients with various degrees of retinopathy had similar increases (p less than 0.05) in their platelet size, while those without complications occupied an intermediate position between normal controls and retinopathy patients. It is concluded that: (i) increased platelet size accompanies diabetic retinopathy, irrespective of its severity, and (ii) patients without this complication form a heterogeneous group, some of which already have alterations of platelet volume. The role of these abnormalities in the development and progression of diabetic microangiopathy remains to be established.
对30名健康对照者和87名糖尿病患者进行血小板体积测量，后者根据是否存在视网膜病变及其严重程度进行细分，以研究血小板大小是否与微血管病变相关。由于大血小板比例较高（p<0.05），整个糖尿病患者群体的血小板体积增加（p<0.05）。不同程度视网膜病变的患者血小板大小有相似程度的增加（p<0.05），而无并发症的患者血小板大小处于正常对照者和视网膜病变患者之间的中间位置。得出以下结论：（i）无论严重程度如何，血小板大小增加都与糖尿病视网膜病变相关；（ii）无此并发症的患者构成一个异质性群体，其中一些患者已经存在血小板体积改变。这些异常在糖尿病微血管病变发生和发展中的作用仍有待确定。
