Chitre A P, Velaskar D S
Dr. Ajit P. Chitre's Clinical Laboratory, Bombay, India.
Angiology. 1988 May;39(5):458-65. doi: 10.1177/000331978803900508.
A study of platelet aggregation in 324 diabetes mellitus (DM) patients and 24 patients with microvascular complications of DM (retinopathy) is reported. Platelet aggregation tests showed that DM patients can be divided into two groups: "normal" and "prone." The mean reading and standard deviation (SD) of the normal group was found to be 22.6% (SD 6.99%). The mean reading and standard deviation of the prone group was found to be 60.5% (SD 12.7%) respectively. All patients with microangiopathy had a significant increase, all of them being in the prone range, with a mean of 69.5% (SD 7.2%). Platelet hyperfunction appears to be a high-risk factor for the development of diabetic microangiopathies. A hypothesis postulating platelet hyperfunction as an additional factor along with altered glycoprotein metabolism and explaining the chain of events in the genesis of diabetic microangiopathies is presented.
报告了一项对324例糖尿病（DM）患者和24例患有DM微血管并发症（视网膜病变）患者的血小板聚集情况的研究。血小板聚集试验表明，DM患者可分为两组：“正常”组和“易聚集”组。发现正常组的平均读数和标准差（SD）为22.6%（SD 6.99%）。易聚集组的平均读数和标准差分别为60.5%（SD 12.7%）。所有微血管病变患者均有显著升高，均处于易聚集范围内，平均值为69.5%（SD 7.2%）。血小板功能亢进似乎是糖尿病微血管病变发生的一个高危因素。提出了一个假设，假定血小板功能亢进是与糖蛋白代谢改变一起的一个额外因素，并解释了糖尿病微血管病变发生过程中的一系列事件。
