Sieberns S, Spechtmeyer H
Int Pharmacopsychiatry. 1982;17(3):170-84.
cis(Z)-Clopenthixol decanoate is a new depot neuroleptic that belongs to the group of thioxanthenes. It has a duration of effect ranging from 2 to 4 weeks and it is used for long-term therapy of chronic schizophrenic patients. The aim of this review is to represent the chemistry, pharmacology, pharmacokinetics, dosage and efficacy of this drug. The target symptoms that essentially call for the application of cis(Z)-clopenthixol decanoate are hostility, suspiciousness and psychomotor restlessness. However, a distinct therapeutic effect has also been observed in patients with hallucinatory-disintegrative and manic syndromes. Moreover, the depot preparation also called forth an emotional stabilization among alcoholics as well as a mitigation of alcohol withdrawal symptoms.
顺式（Z）-癸酸氯哌噻吨是一种新型长效抗精神病药物，属于硫杂蒽类。其作用持续时间为2至4周，用于慢性精神分裂症患者的长期治疗。本综述旨在介绍该药物的化学、药理、药代动力学、剂量及疗效。顺式（Z）-癸酸氯哌噻吨主要适用于的目标症状为敌意、猜疑及精神运动性不安。然而，在患有幻觉-解体和躁狂综合征的患者中也观察到了明显的治疗效果。此外，长效制剂在酗酒者中还能起到情绪稳定作用，并减轻戒酒症状。
