Batata M A, Chu F C, Hilaris B S, Papantoniou P A, Whitmore W F, Golbey R B
Int J Radiat Oncol Biol Phys. 1982 Aug;8(8):1287-93. doi: 10.1016/0360-3016(82)90577-6.
Eight-hundred and thirty-one patients with testicular carcinomas, either teratocarcinoma (405), embryonal carcinoma (406) or pure choriocarcinoma (20), treated mainly at our center from 1950 to 1976, were clinicopathologically staged according to the TNM Classification. The cancer was confined to the body of testis alone (T1 N0 M0) or extended to paratesticular structures (T2-4 N0 M0) in 37% of all patients. Para-aortic lymph nodes were found involved (N1-3) in 33% and juxtaregional lymph nodes (N4) in 9% of patients; distant metastases were detected initially in the lung alone (M1) and other distant organs (M2) in 21% of the patients. Postorchiectomy treatment was retroperitoneal lymphadenectomy with or without regional-juxtaregional irradiation and systemic chemotherapy in 470 patients; the other 361 patients received external irradiation and/or adjuvant chemotherapy. Survival determined at 5 years was 58% in teratocarcinoma cases, 41% in embryonal carcinoma cases and 0% in pure choriocarcinoma cases. Rates of 5-year survival according to the TNM staging were 81% for T1 N0 M0 tumors, 58% for T2-4 N0 M0 tumors, 44% for N1-3 M0 tumors, 33% for N4 M0 tumors and 10% for N0-4 M1 or 2 tumors. In patients who underwent lymphadenectomy with or without external irradiation, the 5-year survival rates with and without adjuvant chemotherapy, respectively, were 96% and 86% for T1 N0 M0 tumors, 100% and 60% for T2-4 N0 M0 tumors, 66% and 42% for N1-3 M0 tumors, 54% and 40% for N4 M0 tumors and 38% and 0% for N0-4 M1 tumors. In patients treated by external irradiation alone or following lymphadenectomy the rates of 5-year survival with versus without adjuvant chemotherapy were 100% versus 66% for T1-4 N0 M0 tumors, 44% versus 18% for N1-3 M0 tumors, 41% versus 22% for N4 M0 tumors and 3% versus 4% for N0-4 M1-2 tumors.
1950年至1976年期间，主要在我们中心接受治疗的831例睾丸癌患者，包括畸胎癌（405例）、胚胎癌（406例）或纯绒毛膜癌（20例），根据TNM分类进行了临床病理分期。在所有患者中，37%的癌症仅局限于睾丸体部（T1 N0 M0）或扩展至睾丸旁结构（T2 - 4 N0 M0）。33%的患者发现腹主动脉旁淋巴结受累（N1 - 3），9%的患者发现区域旁淋巴结受累（N4）；21%的患者最初在肺部单独发现远处转移（M1），在其他远处器官发现远处转移（M2）。470例患者在睾丸切除术后接受了腹膜后淋巴结清扫术，伴或不伴区域 - 区域旁照射及全身化疗；其他361例患者接受了外照射和/或辅助化疗。畸胎癌病例的5年生存率为58%，胚胎癌病例为41%，纯绒毛膜癌病例为0%。根据TNM分期的5年生存率，T1 N0 M0肿瘤为81%，T2 - 4 N0 M0肿瘤为58%，N1 - 3 M0肿瘤为44%，N4 M0肿瘤为33%，N0 - 4 M1或2肿瘤为10%。在接受或未接受外照射的淋巴结清扫术患者中，T1 N0 M0肿瘤接受和未接受辅助化疗的5年生存率分别为96%和86%，T2 - 4 N0 M0肿瘤分别为100%和60%，N1 - 3 M0肿瘤分别为66%和42%，N4 M0肿瘤分别为54%和40%，N0 - 4 M1肿瘤分别为38%和0%。在仅接受外照射或在淋巴结清扫术后接受治疗的患者中，T1 - 4 N0 M0肿瘤接受与未接受辅助化疗的5年生存率分别为100%和66%，N1 - 3 M0肿瘤分别为44%和18%，N4 M0肿瘤分别为41%和22%，N0 - 4 M1 - 2肿瘤分别为3%和4%。
