Ishizuka M, Ishizeki S, Masuda T, Momose A, Aoyagi T, Takeuchi T, Umezawa H
J Antibiot (Tokyo). 1982 Aug;35(8):1042-8. doi: 10.7164/antibiotics.35.1042.
The oral administration of forphenicinol, S-2-(3-hydroxy-4-hydroxymethylphenyl)glycine which was synthesized during the study of derivatives and analogs of forphenicine, augmented delayed-type hypersensitivity to sheep red blood cells and oxazolone in mice. The treatment with forphenicinol restored DTH in mice immuno-suppressed by cyclophosphamide to normal response. Forphenicinol neither augmented antibody-formation nor stimulated proliferation of lymphocytes in the presence or absence of lectins. Phagocytosis by peritoneal macrophages was enhanced by forphenicinol in vivo and in vitro. Forphenicinol was effective in increasing the production of CFU-C in the presence of colony stimulating factor and partially prevented the reduction of leucocyte counts caused by mitomycin C.
在对福吩尼辛的衍生物和类似物的研究过程中合成的S-2-(3-羟基-4-羟甲基苯基)甘氨酸（即福吩尼醇）经口服后，增强了小鼠对绵羊红细胞和恶唑酮的迟发型超敏反应。用福吩尼醇治疗可使被环磷酰胺免疫抑制的小鼠的迟发型超敏反应恢复到正常水平。无论有无凝集素存在，福吩尼醇既不增强抗体形成，也不刺激淋巴细胞增殖。福吩尼醇在体内和体外均可增强腹膜巨噬细胞的吞噬作用。在集落刺激因子存在的情况下，福吩尼醇能有效增加集落形成单位-细胞（CFU-C）的产生，并部分预防丝裂霉素C引起的白细胞计数减少。
