Naito K, Arakawa H, Watanabe Y, Okura A, Ishizuka M, Takeuchi T, Umezawa H
J Antibiot (Tokyo). 1987 Apr;40(4):547-54. doi: 10.7164/antibiotics.40.547.
The oral administration of forphenicinol increased the survival rate of both normal and immunodepressed mice intraperitoneally or intratracheally infected with clinically isolated strains of Pseudomonas aeruginosa. The therapeutic effect of amikacin on intraperitoneal infection with P. aeruginosa was enhanced by combined use with forphenicinol. Forphenicinol did not enhance the bactericidal activity of polymorphonuclear cells (PMN) towards P. aeruginosa in vitro, but enhanced it in vivo. In vitro study indicated that the macrophages taken from mice treated with forphenicinol or the cultured supernatant of these macrophages enhanced the bactericidal activity of PMN. The protective effect of forphenicinol against P. aeruginosa infection was thus suggested to be due to macrophage activation followed by the enhancement of the bactericidal activity of PMN.
口服福酚美克可提高正常小鼠和免疫抑制小鼠经腹腔或气管内感染临床分离的铜绿假单胞菌菌株后的存活率。与福酚美克联合使用可增强阿米卡星对铜绿假单胞菌腹腔感染的治疗效果。福酚美克在体外不会增强多形核细胞（PMN）对铜绿假单胞菌的杀菌活性，但在体内会增强。体外研究表明，取自用福酚美克处理的小鼠的巨噬细胞或这些巨噬细胞的培养上清液可增强PMN的杀菌活性。因此，福酚美克对铜绿假单胞菌感染的保护作用被认为是由于巨噬细胞活化，随后PMN的杀菌活性增强。
