Janin-Mercier A, Sauvezie B, Ristori J M, Betail G, Veyre A, Rampon S
J Clin Immunol. 1982 Oct;2(4):282-8. doi: 10.1007/BF00915068.
We report the histological and immunological findings in 20 rheumatoid arthritis (RA) patients with impaired salivary scintigraphy but without sicca complex. This condition was stable over 2-5 years and associated with mild infiltrates on lip biopsies. Increased levels of IgG, immune complexes, and antinuclear antibodies were found in seven patients (35 vs 69% in secondary Sjögren's syndrome). Two of the seven patients later developed xerostomia. The above-mentioned immunological abnormalities may increase the likelihood of developing a clinical impairment of salivary function in patients with an abnormal salivary scintiscan, the latter being a frequent, yet often isolated, finding in RA. Antisalivary duct antibodies were not related to any other parameter of salivary gland involvement.
我们报告了20例类风湿关节炎（RA）患者的组织学和免疫学检查结果，这些患者唾液闪烁扫描结果异常，但无干燥综合征。这种情况在2至5年期间保持稳定，唇部活检显示有轻度浸润。7例患者（35%）发现IgG、免疫复合物和抗核抗体水平升高（继发性干燥综合征患者中这一比例为69%）。7例患者中有2例后来出现口干症状。上述免疫学异常可能增加唾液闪烁扫描异常的RA患者出现唾液功能临床损害的可能性，唾液闪烁扫描异常在RA患者中很常见，但往往是孤立出现的。抗唾液腺导管抗体与唾液腺受累的其他任何参数均无关联。
