Fischbach M, Char D, Christensen M, Daniels T, Whaley K, Alspaugh M, Talal N
Arthritis Rheum. 1980 Jul;23(7):791-5. doi: 10.1002/art.1780230703.
Sera from 48 patients with Sjögren's syndrome were examined for immune complexes by the Raji cell assay. There was no correlation between levels of immune complexes and the degree of lymphocytic infiltration of the labial salivary glands. Serum complement levels were normal. Five patients were serially followed during the development of pseudolymphoma or malignant lymphoma. Immune complex levels in 4 of the 5 patients were generally unchanged throughout the illness and did not parallel disease activity, rheumatoid factor, or SS-A and SS-B concentrations. Possible roles for immune complexes in Sjögren's syndrome are discussed.
采用Raji细胞试验检测了48例干燥综合征患者血清中的免疫复合物。免疫复合物水平与唇唾液腺淋巴细胞浸润程度之间无相关性。血清补体水平正常。对5例在假性淋巴瘤或恶性淋巴瘤发生过程中进行了连续随访。5例患者中有4例的免疫复合物水平在整个病程中基本未变，与疾病活动度、类风湿因子或SS - A和SS - B浓度无关。文中讨论了免疫复合物在干燥综合征中的可能作用。
