Powell D A, Milligan W L, Mull P
J Comp Physiol Psychol. 1982 Oct;96(5):742-54. doi: 10.1037/h0077929.
New Zealand albino rabbits received sham lesions or complete, medial, lateral, or posterior septal lesions and were subjected to differential conditioning in which tones of different frequencies served as conditioned stimuli and paraorbital electric shock was the unconditioned stimulus. Electromyographic (EMG), heart rate (HR), and blood pressure (BP) conditioned responses (CRs) as well as hippocampal rhythmic slow wave activity (RSA) were recorded. Lateral or complete septal lesions enhanced the bradycardiac HR CR but had no effect on the BP depressor response. Both unconditioned and conditioned EMG responses occurred infrequently and were unaffected by any lesion. Unconditioned HR responses and somatomotor threshold determinations to unsignaled electric shock were also unaffected by the lesions. Complete septal lesions increased locomotor activity relative to sham or other septal lesions. Little hippocampal RSA was detected in animals with medial lesions, but the HR CR was unimpaired in these animals. These data implicate the septo-hippocampal circuit in classical conditioning of cardiovascular changes and further suggest that diencephalic forebrain structures may modulate forebrain processing of sensory stimulation, perhaps in terms of assessing its biological significance.
新西兰白化兔接受假损伤或完全、内侧、外侧或后部隔区损伤，并接受辨别性条件反射训练，其中不同频率的音调作为条件刺激，眶旁电击作为非条件刺激。记录肌电图（EMG）、心率（HR）和血压（BP）条件反应（CRs）以及海马节律性慢波活动（RSA）。外侧或完全隔区损伤增强了心动过缓的HR CR，但对BP降压反应没有影响。非条件和条件EMG反应很少发生，且不受任何损伤的影响。非条件HR反应和对未发出信号的电击的躯体运动阈值测定也不受损伤的影响。相对于假损伤或其他隔区损伤，完全隔区损伤增加了运动活动。在内侧损伤的动物中几乎检测不到海马RSA，但这些动物的HR CR未受损。这些数据表明隔-海马回路参与心血管变化的经典条件反射，并进一步表明间脑前脑结构可能调节前脑对感觉刺激的处理，也许是在评估其生物学意义方面。
