Veitia M C, King B M, Levine S
J Comp Physiol Psychol. 1982 Oct;96(5):846-9. doi: 10.1037/h0077930.
Plasma corticosterone levels were used to assess the response to stress induced by intraperitoneal injections of hypertonic saline in rats with lateral hypothalamic (LH) or sham lesions. Rats with LH lesions displayed a corticosterone response equal to that of normal animals under basal conditions, after control injections of isotonic saline, and 20 min after injection of hypertonic saline (1.5 M, 1.0 ml/100 g of body weight). The corticosterone response of animals with LH lesions, however, was significantly less than that of normal animals 90 min after injection of hypertonic saline when no water was available. With access to water, normal animals displayed substantial drinking (14.5 ml/90 min), which resulted in a reduction in plasma corticosterone concentrations to a level observed after a control injection of isotonic saline, but the little water ingested by animals with LH lesions (2.5 ml) had no effect on the pituitary-adrenal system. It is concluded that the failure of animals with LH lesions to drink following a hydrational challenge is not the result of an exaggerated response to stress.
利用血浆皮质酮水平来评估下丘脑外侧（LH）损伤或假损伤大鼠对腹腔注射高渗盐水所诱导应激的反应。LH损伤大鼠在基础条件下、注射等渗盐水作为对照后以及注射高渗盐水（1.5 M，1.0 ml/100 g体重）20分钟后，其皮质酮反应与正常动物相当。然而，当无水可饮时，注射高渗盐水90分钟后，LH损伤动物的皮质酮反应明显低于正常动物。在有水可饮的情况下，正常动物大量饮水（14.5 ml/90分钟），这导致血浆皮质酮浓度降至对照注射等渗盐水后所观察到的水平，但LH损伤动物摄入的少量水（2.5 ml）对垂体-肾上腺系统没有影响。得出的结论是，LH损伤动物在水合挑战后不能饮水并非对应激反应过度的结果。
