Tuckett R P
J Invest Dermatol. 1982 Dec;79(6):368-73. doi: 10.1111/1523-1747.ep12529734.
Psychophysical experiments were done to test the possibility that a single receptor population signals both itch and pain by generating different patterns of activity for each type of stimulus. Electrical stimulation of hairy skin evoked pruritus in 92% of the subjects tested, and for the majority the pruritus elicited by electrical stimulation felt the same as that provoked by cowhage. The intensity of pruritus increased with the frequency of stimulation with no change in the quality of the sensation from itch to pain. Electrical stimulation of human skin with response patterns obtained from individual cat polymodal nociceptive neurons to pain- and itch-producing stimuli caused no differences in the quality of the evoked pruritic sensations. These results do not support the idea that the same population of primary sensory neurons can produce both itch and pain by changing their pattern of discharge.
进行了心理物理学实验，以测试单一感受器群体通过为每种类型的刺激产生不同的活动模式来同时传递瘙痒和疼痛信号的可能性。对有毛皮肤进行电刺激，在92%的受试对象中诱发了瘙痒，并且对于大多数人来说，电刺激引起的瘙痒感觉与刺荨麻引起的瘙痒相同。瘙痒强度随刺激频率增加，而感觉性质从瘙痒到疼痛没有变化。用人皮肤进行电刺激，采用从单个猫多模式伤害性神经元对产生疼痛和瘙痒的刺激所获得的反应模式，所诱发的瘙痒感觉性质没有差异。这些结果不支持同一群初级感觉神经元可通过改变其放电模式同时产生瘙痒和疼痛的观点。
