Benedetto J P, Ortonne J P, Voulot C, Khatchadourian C, Prota G, Thivolet J
J Invest Dermatol. 1982 Dec;79(6):422-4. doi: 10.1111/1523-1747.ep12530631.
Previously, we reported evidence suggesting that, in addition to tyrosinase, glutathione-reductase plays an important role in the regulation and control of the biosynthetic activity of melanocytes. Further investigations were performed on a mammal presenting a well-defined genotype for coat pigmentation, the mutant mouse [subline C57 BL (6J)], namely the nonagouti black (a/a) mutant and the yellow (Ay/a) mutant showing, respectively, pure uniform eumelanin and phaeomelanin pigmentation. Analysis of thiol compounds and glutathione-related enzyme levels in mouse skin gave similar results to those found in tortoise-shell guinea pig skin. The observed differences in the glutathione and glutathione-related enzyme content between black and yellow (or red) skin provide evidence that the increase of glutathione-reductase activity in the environment of the melanocytes may stimulate the pigment cells to produce phaeomelanin instead of eumelanin pigment.
此前，我们报告的证据表明，除了酪氨酸酶外，谷胱甘肽还原酶在黑素细胞生物合成活性的调节和控制中也起着重要作用。我们对一种具有明确被毛色素沉着基因型的哺乳动物——突变小鼠[C57 BL(6J)亚系]进行了进一步研究，即非刺豚鼠黑色(a/a)突变体和黄色(Ay/a)突变体，它们分别呈现出纯一的真黑素和褐黑素色素沉着。对小鼠皮肤中硫醇化合物和谷胱甘肽相关酶水平的分析结果与玳瑁色豚鼠皮肤中的结果相似。在黑色和黄色（或红色）皮肤之间观察到的谷胱甘肽和谷胱甘肽相关酶含量差异表明，黑素细胞环境中谷胱甘肽还原酶活性的增加可能会刺激色素细胞产生褐黑素而非真黑素。
