Mizutani R, Nakano K
J Nutr. 1982 Dec;112(12):2205-11. doi: 10.1093/jn/112.12.2205.
The effect of vitamin A depletion on stress-induced change in sympathoadrenal medullary activity was studied in rats. Four consecutive hours daily of immobilization provoked a marked increase in urinary excretion of free norepinephrine (NE) and epinephrine (E), confirming previous findings. The stress caused a significant decrease in output of free dopamine (DA). In contrast, the vitamin A-depleted rats in the resting state excreted threefold more NE in urine as compared with the normal animals. The urinary NE response to the stress was markedly diminished in the depleted rats, although E and DA responses to the stress were similar in magnitude to those in the normal animals. These results suggest that vitamin A depletion causes derangement of the neurosympathetic system; hence, the animals cannot appropriately respond to the stress. Alternatively, the state of vitamin A depletion may be fact a stress, and in consequence the animals have already been in a state of maximal response before immobilization.
研究了维生素A缺乏对大鼠应激诱导的交感肾上腺髓质活动变化的影响。每天连续4小时固定大鼠诱发游离去甲肾上腺素（NE）和肾上腺素（E）尿排泄显著增加，证实了先前的研究结果。应激导致游离多巴胺（DA）分泌显著减少。相比之下，处于静息状态的维生素A缺乏大鼠尿中NE排泄量比正常动物多两倍。缺乏维生素A的大鼠对应激的尿NE反应明显减弱，尽管E和DA对应激的反应幅度与正常动物相似。这些结果表明，维生素A缺乏导致神经交感系统紊乱；因此，动物无法对应激做出适当反应。或者，维生素A缺乏状态可能实际上是一种应激，结果动物在固定前就已经处于最大反应状态。
