Aksel S, Schomberg D W, Hammond C B
Obstet Gynecol. 1978 Oct;52(4):421-3.
It has been demonstrated that the ovary bearing the corpus luteum in the human is responsible for the major portion of prostaglandin F2alpha (PGF2alpha), total estrogen, and progestin production during the luteal phase of a normal menstrual cycle. This study was performed with the intent to gain more information about the secretion of PGF2alpha in conditions that prolong the life span of the corpus luteum, such as pregnancy and Halban's disease. Utilizing a specific radioimmunoassay for PGF2alpha, ovarian venous plasma levels were measured in 7 pregnant women and in a patient with Halban's disease. During the first and second trimester of pregnancy, PGF2alpha values in plasma from the active and inactive ovary were comparable and were significantly lower than concentrations in plasma from the active ovary during the luteal phase of the normal cycle. In a patient with persistent corpus luteum or Halban's disease, PGF2alpha concentrations of venous plasma from the ovary bearing the corpus luteum were significantly lower than those obtained from the contralateral ovary. These observations indirectly support the hypothesis that prostaglandins produced within the ovary may have a role in luteal regression.
业已证明，在正常月经周期的黄体期，人类体内带有黄体的卵巢是前列腺素F2α（PGF2α）、总雌激素和孕激素产生的主要来源。本研究旨在获取更多关于在延长黄体寿命的情况下，如妊娠和哈尔班氏病中PGF2α分泌的信息。利用针对PGF2α的特异性放射免疫测定法，对7名孕妇和1名患有哈尔班氏病的患者的卵巢静脉血浆水平进行了测量。在妊娠的前三个月和第二个三个月期间，来自活跃和不活跃卵巢的血浆中PGF2α值相当，且显著低于正常周期黄体期来自活跃卵巢的血浆浓度。在患有持续性黄体或哈尔班氏病的患者中，来自带有黄体的卵巢的静脉血浆中PGF2α浓度显著低于对侧卵巢。这些观察结果间接支持了卵巢内产生的前列腺素可能在黄体退化中起作用的假说。
