Nair R, Kamat R S
J Med Microbiol. 1982 May;15(2):215-21. doi: 10.1099/00222615-15-2-215.
Effector responses of cell-mediated immunity were studied in mice immediately and 3 months after immunisation with different kinds of salmonella vaccine. Whereas immunisation with live Salmonella enteritidis generated delayed hypersensitivity and activated macrophages, immunisation with formalised vaccine generated neither. Although activated macrophages had declined considerably by 3 months after immunisation, the delayed-hypersensitivity response had persisted. It was possible to generate activated macrophages in these mice by stimulation with sonicate antigens of the immunising strain or Salmonella paratyphic C. Delayed-hypersensitivity responses were elicited in mice, immunised with live S. enteritidis, by sonicate antigens of the homologous strains, S. gallinarum or S. paratyphi C.
在小鼠用不同种类的沙门氏菌疫苗免疫后即刻和3个月时，研究了细胞介导免疫的效应反应。用活肠炎沙门氏菌免疫可产生迟发型超敏反应并激活巨噬细胞，而用灭活疫苗免疫则两者均未产生。尽管免疫后3个月时活化巨噬细胞已大幅减少，但迟发型超敏反应仍持续存在。通过用免疫菌株或副伤寒沙门氏菌C的超声破碎抗原刺激，可在这些小鼠中产生活化巨噬细胞。用同源菌株鸡沙门氏菌或副伤寒沙门氏菌C的超声破碎抗原，可在已用活肠炎沙门氏菌免疫的小鼠中引发迟发型超敏反应。
