摄入致死剂量马拉硫磷中毒时其在体内的分布及代谢产物情况
Body distribution of malathion and its metabolites in a fatal poisoning by ingestion.
作者信息
Morgade C, Barquet A
出版信息
J Toxicol Environ Health. 1982 Aug;10(2):321-5. doi: 10.1080/15287398209530254.
Eight autopsy samples from an individual who had ingested a large amount of malathion were analyzed fo four components: intact pesticide, malaoxon, malathion monocarboxylic acid (MCA), and malathion dicarboxylic acid (DCA). Malathion was present in all samples except liver. Highest concentrations were found in the gastric contents (8621 ppm) and adipose tissue (76.4 ppm). Malaoxon was identified in some tissues at very low levels; a significant amount was found only in fat (8.2 ppm). The MCA and DCA were detected in all tissue. The former was found in greater abundance: 221 ppm in bile, 106 ppm in kidney, and 103 ppm in the gastric contents.
对一名摄入大量马拉硫磷的个体的八份尸检样本进行了四种成分分析
完整农药、马拉氧磷、一硫代磷酸单羧酸（MCA）和二硫代磷酸二羧酸（DCA）。除肝脏外，所有样本中均存在马拉硫磷。在胃内容物（8621 ppm）和脂肪组织（76.4 ppm）中发现了最高浓度。在一些组织中检测到极低水平的马拉氧磷；仅在脂肪中发现了大量的马拉氧磷（8.2 ppm）。在所有组织中均检测到了MCA和DCA。前者含量更高：胆汁中为221 ppm，肾脏中为106 ppm，胃内容物中为103 ppm。
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