Cooney D O
J Toxicol Clin Toxicol. 1982 Jun;19(4):367-76. doi: 10.3109/15563658208992490.
The effect of the type of carboxymethylcellulose (CMC) and amount of CMC used in preparing antidotal charcoal formulations on the in vitro kinetics of sodium salicylate adsorption from simulated gastric fluid was assessed in agitated vessels of two designs. Mixtures made with low, medium, and high viscosity CMC were tested. Additionally, the effects of the charcoal and water contents of these mixtures on adsorption kinetics were considered. The results suggest that charcoal mixtures which are fluid enough to be pourable (hence, drinkable) are strongly to be preferred from the standpoint of rate of adsorption. More particularly, gel-like formulations should be avoided because they disperse poorly and result in rather slow rates of drug uptake.
在两种设计的搅拌容器中，评估了制备解毒炭制剂时所用羧甲基纤维素（CMC）的类型和用量对模拟胃液中水杨酸钠吸附体外动力学的影响。测试了用低、中、高粘度CMC制成的混合物。此外，还考虑了这些混合物中活性炭和水含量对吸附动力学的影响。结果表明，从吸附速率的角度来看，流动性足以倾倒（因此可饮用）的活性炭混合物是非常可取的。更具体地说，应避免使用凝胶状制剂，因为它们分散性差，导致药物吸收速度相当缓慢。
