Taylor G A, Mellits E D, Zinkham W H, Leventhal B G
Med Pediatr Oncol. 1982;10(5):489-96. doi: 10.1002/mpo.2950100509.
We retrospectively studied intravenous urograms (IVU) performed at presentation on 108 children with acute leukemia in order to determine whether any association existed between an abnormal IVU and known prognostic factors at presentation, initial renal function, and outcome. Sixteen patients (14%) had abnormal IVUs. These patients were compared to the remainder of the group and found to be comparable in respect to known prognostic factors at diagnosis (P greater than 0.05). No correlation was found between abnormal renal function and an abnormal IVU. Renal enlargement was associated with shorter survival only in patients who had both adenopathy and hepatosplenomegaly (P less than 0.01). This effect did not persist in any other group of patients examined. When subjected to multivariate analysis the IVU did not significantly influence relapse or survival in these patients. Renal enlargement may be a prognostic feature in some patients with childhood leukemia. Nevertheless routine evaluation by IVU is discouraged because of potential adverse affects of urographic contrast media and the availability of noninvasive ultrasound techniques.
我们回顾性研究了108例急性白血病患儿就诊时进行的静脉肾盂造影（IVU），以确定IVU异常与就诊时已知的预后因素、初始肾功能及预后之间是否存在关联。16例患者（14%）IVU异常。将这些患者与该组其余患者进行比较，发现他们在诊断时已知的预后因素方面具有可比性（P大于0.05）。未发现肾功能异常与IVU异常之间存在相关性。仅在同时患有腺病和肝脾肿大的患者中，肾脏肿大与较短的生存期相关（P小于0.01）。在其他任何一组接受检查的患者中，这种影响均未持续存在。在进行多变量分析时，IVU对这些患者的复发或生存期没有显著影响。肾脏肿大可能是一些儿童白血病患者的预后特征。然而，由于尿路造影剂的潜在不良影响以及无创超声技术的可用性，不建议进行常规IVU评估。
