Barragry J M, France M W, Carter N D, Auton J A, Beer M, Boucher B J, Cohen R D
Lancet. 1977 Sep 24;2(8039):629-32. doi: 10.1016/s0140-6736(77)92498-9.
Plasma concentrations of 25-hydroxy-cholecalciferol (25-OHD3) and vitamin-D-binding globulin (V.D.B.G.) were significantly reduced in ten nephrotic subjects. V.D.B.G., which is undetectable in normal urine, was present in substantial amounts in the urine of each nephrotic subject. Administration of 3H-labelled cholecalciferol to three subjects resulted in the rapid appearance of the labelled vitamin in the urine, mainly as the 25-hydroxylated metabolite bound to V.D.B.G. in amounts which could largely account for the low plasma-25-OHD3. The plasma half-life of 25-OHD3 was substantially reduced in the nephrotic syndrome.
十名肾病患者的血浆中25-羟胆钙化醇（25-OHD3）和维生素D结合球蛋白（V.D.B.G.）浓度显著降低。正常尿液中无法检测到的V.D.B.G.在每名肾病患者的尿液中大量存在。给三名患者服用3H标记的胆钙化醇后，标记维生素迅速出现在尿液中，主要是以与V.D.B.G.结合的25-羟基代谢产物形式，其含量在很大程度上可以解释血浆25-OHD3水平较低的原因。肾病综合征患者中25-OHD3的血浆半衰期大幅缩短。
