Jung R T, Davie M, Hunter J O, Chalmers T M, Lawson D E
Gut. 1978 Apr;19(4):290-3. doi: 10.1136/gut.19.4.290.
Vitamin D metabolism was investigated in 10 patients with cirrhosis. Mean plasma 25 hydroxycholecalciferol (25 OHD) centration in alcoholic cirrhosis was lower than in controls but the difference was not significant. In three patients restudied after the summer, plasma 25 OHD had risen. In contrast to the finding in normal subjects, the half-life of intravenously administered 3H cholecalciferol was short in cirrhotics and showed no correlation with plasma 25 OHD. Furthermore, the appearance of 3H 25 OHD from 3H cholecalciferol was reduced compared to the control group four hours after injection. Increased rate of metabolism of cholecalciferol and deficient production of 25 ohd contribute to vitamin D deficiency in liver disease.
对10例肝硬化患者的维生素D代谢情况进行了研究。酒精性肝硬化患者血浆中25羟胆钙化醇(25OHD)的平均浓度低于对照组,但差异不显著。在夏季后重新研究的3例患者中,血浆25OHD有所升高。与正常受试者的研究结果相反,肝硬化患者静脉注射3H胆钙化醇后的半衰期较短,且与血浆25OHD无相关性。此外,注射后4小时,与对照组相比,3H胆钙化醇生成3H 25OHD的量减少。胆钙化醇代谢速率增加和25OHD生成不足导致了肝脏疾病中的维生素D缺乏。