Schabel F
Padiatr Padol. 1978;13(4):385-90.
There are a few scattered publications on primary tubulopathies, where a net secretion of phosphorus by renal tubules, a mechanism usually not existing in man, is shown. By means of a further case, we are able to demonstrate a 30% increase of phosphate excretion over filtration after a phosphate load. The mechanism of action will be discussed. Under certain conditions like a rapid increase in serum phosphorus or after volume expansion a tubular secretory mechanism of phosphate can be unmasked. As this secretory mechanism goes into action only beyond a certain serum threshold of phosphorus and a transport maximum cannot be shown it is most likely that passive transport by means of an increased diffusion cell to lumen is the proposed mechanism involved.
关于原发性肾小管疾病有一些零散的出版物，其中显示肾小管存在磷的净分泌，而这一机制在人类中通常并不存在。通过另一个病例，我们能够证明在给予磷酸盐负荷后，磷酸盐排泄量比滤过量增加了30%。将讨论其作用机制。在某些情况下，如血清磷快速升高或容量扩张后，磷酸盐的肾小管分泌机制可能会显现出来。由于这种分泌机制仅在超过一定的血清磷阈值时才起作用，且无法显示出转运最大值，因此最有可能涉及的机制是通过增加扩散从细胞到管腔的被动转运。
