Biegon A, Fischette C T, Rainbow T C, McEwen B S
Neuroendocrinology. 1982 Oct;35(4):287-91. doi: 10.1159/000123396.
The effect of estradiol on serotonin (5HT1) receptors of ovariectomized female rats was studied in discrete brain nuclei by a micro-binding assay and quantitative autoradiography. The two methods show similar distribution of the 5HT1 receptor and estradiol significantly increases the density of receptors in the preoptic area, anterior hypothalamus, lateral septum and arcuate-median eminence. The increase in 5HT1 receptors in these particular nuclei may be related to estrogen control of ovulation and/or other estrogen-mediated central phenomena.
通过微量结合测定法和定量放射自显影技术，在离散的脑核中研究了雌二醇对去卵巢雌性大鼠5-羟色胺（5HT1）受体的影响。这两种方法显示5HT1受体的分布相似，并且雌二醇显著增加了视前区、下丘脑前部、外侧隔和弓状正中隆起中受体的密度。这些特定核团中5HT1受体的增加可能与雌激素对排卵的控制和/或其他雌激素介导的中枢现象有关。
