Biegon A, McEwen B S
J Neurosci. 1982 Feb;2(2):199-205. doi: 10.1523/JNEUROSCI.02-02-00199.1982.
Estrogens were found to exert a biphasic effect on the density of serotonin receptors in the female rat brain: an acute reduction in serotonin receptor density throughout the brain is followed 48 to 72 hr later by a selective increase in those brain regions known to contain estrogen receptors--hypothalamus, preoptic area, and amygdala. The acute reduction in serotonin receptor density can be mimicked by estradiol in vitro. We conclude that estradiol may have a fast, direct effect on brain membranes to modify serotonin receptor availability, while exerting a slow effect on the same receptors through an interaction with intracellular estrogen receptors in those brain regions that contain them. The observation that female sex hormones are involved in the regulation of serotonin receptors may have important implications in the understanding of female sexual behavior in the female rat and in the understanding of hormone-linked emotional disturbances in women.
研究发现，雌激素对雌性大鼠大脑中血清素受体的密度具有双相作用：大脑中血清素受体密度会先急剧降低，48至72小时后，已知含有雌激素受体的脑区（下丘脑、视前区和杏仁核）中的血清素受体密度会选择性增加。体外实验中，雌二醇可模拟血清素受体密度的急性降低。我们得出结论，雌二醇可能对脑膜有快速直接的作用，以改变血清素受体的可利用性，同时通过与含有雌激素受体的脑区中的细胞内雌激素受体相互作用，对相同受体产生缓慢作用。雌性激素参与血清素受体调节这一观察结果，可能对理解雌性大鼠的性行为以及女性激素相关的情绪障碍具有重要意义。
