Vidal C, Jacob J
Neurosci Lett. 1982 Sep 20;32(1):75-80. doi: 10.1016/0304-3940(82)90232-4.
Stress-induced analgesia is well known but the reverse phenomenon is poorly documented. In this work, hyperalgesia is described following stressful but non-noxious manipulations consisting of inescapable holding or exposure to a novel environment. Hypophysectomy (HX) and dexamethasone enhanced 'holding' hyperalgesia. In contrast, 'novelty' hyperalgesia was reduced by HX and not modified by dexamethasone. So, pituitary factors may respectively compensate and take part in stress hyperalgesia. Thus pain can be modulated in opposite directions by different types of stimulation: hyperalgesia would predominate after moderate, anxiogenic stress and analgesia after noxious and/or intense stress.
应激诱导的镇痛作用广为人知，但相反的现象却鲜有文献记载。在这项研究中，描述了在由无法逃避的握持或暴露于新环境组成的应激但非有害操作后出现的痛觉过敏。垂体切除（HX）和地塞米松增强了“握持”痛觉过敏。相反，HX降低了“新奇”痛觉过敏，而地塞米松对其无影响。因此，垂体因子可能分别起到补偿作用并参与应激性痛觉过敏。所以，疼痛可通过不同类型的刺激在相反方向上得到调节：中度、致焦虑应激后痛觉过敏占主导，而有害和/或强烈应激后则出现镇痛作用。
